The 23-time Grand Slam singles champion made her return to tennis in June, four years after "evolving away" from the sport.
She has played three doubles matches since her return and made her singles comeback at Wimbledon, losing in three sets to Maya Joint.
The American great lost in the doubles with elder sister Venus at the Cincinnati Open on Monday in her first match since injuring her knee at Wimbledon.
The pair, who have a combined 44 singles and doubles Grand Slams, have been given a wildcard into the main draw of the competition.
The top six pairs with the best combined singles rankings have received direct entry into the main draw, with another eight receiving wildcards.
Defending champions Sara Errani and Andrea Vavassori are the only doubles specialist pairing to receive a main-draw wildcard.
The other pairings - including Britain's number one Henry Patten alongside top-ranked women's player Katerina Siniakova - will have to come through an eight-team qualifying round.
The competition takes place from 24-26 August, finishing four days before the singles draw begins.
Other high-profile pairings include world number one Aryna Sabalenka with 24-time major champion Novak Djokovic, Australian Open champion Elena Rybakina and Taylor Fritz and six-time major champion Iga Swiatek and Casper Ruud.
Ukraine's Elina Svitolina has paired up with husband Gael Monfils in the Frenchman's final Grand Slam before retirement.
The tournament was revamped last year to include more pairings involving singles players - something that was criticised by a number of doubles specialists.
A shorter scoring system was introduced, with only four games required to win a set in matches before the final, no 'advantage' scoring and 10-point match tie-breaks instead of a third set throughout.
The tournament was also tweaked to place over two days in the week before the main draw began.
Italians Errani and Vavassori - the only doubles specialist pairing invited to compete last year - last year issued a joint statement criticising the "profoundly wrong" move.
However, the pair ended up walking away with the title - and $1m (£740,000) in prize money - and said afterwards they had "completed their mission".
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