Start Marcus Rashford? Bring Nico O'Reilly and John Stones back in? Rest Declan Rice?
The England head coach made two changes for Tuesday's second World Cup group game, with Djed Spence and Marc Guehi coming in for O'Reilly and Stones in a 0-0 draw with Ghana. But what will he do on Sunday against Panama?
"I think Tuchel will change it up," former England forward Alan Shearer told BBC Sport.
"Bukayo Saka and Rashford have definitely done enough when they have come on in both games to get a chance to start.
"Another change I can see happening is at left-back, with O'Reilly coming back in for Spence."
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