Make New York Post a Preferred Source Arizona Cardinals tight end Trey McBride pauses on the field during an NFL football game against the New York Giants, in East Rutherford, N.J., Sunday, Oct. 4, 2026. AP Photo/Seth Wenig If you’re new to prediction markets, you can use the Novig promo code NYPOST to deposit $10 and get $50 in trade credits for Lions vs. Cardinals.
The Lions head to Arizona looking to get back above .500 behind an explosive offense that has spent the opening month compensating for one of the NFL’s worst defenses.
Detroit is favored by 4.5 points against a Cardinals team riding a three-game losing streak, with the Lions’ sixth-ranked offense in EPA per play.
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The Lions rank dead last in opponent EPA per play and have surrendered at least 30 points in three of four games, while the Cardinals have allowed 30 or more in three straight.
Detroit’s defensive problems could be particularly troublesome against tight end Trey McBride, especially with Arizona’s Jacoby Brissett needing to keep pace with Jared Goff’s busy trigger.
The Over has cashed in all four Lions games this season, helping push Sunday’s total to a lofty 54.5 points. However, the Under hitting in four of the last five meetings between these teams.
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Sean Treppedi handicaps the NFL, NHL, MLB and college football for the New York Post. He primarily focuses on picks that reflect market value while tracking trends to mitigate risk.
