The Dark Blues made a blistering start to the 80th edition of the race and Cambridge were unable to respond.
In tricky, blustery conditions on the 4.2-mile Putney to Chiswick course, the Oxford crew had to dig deep as Cambridge tried everything to bridge the gap.
But Oxford stayed strong, maintaining their advantage to win by 9.4 seconds and celebrate their 31st overall success.
More to follow